Be careful! Five major diseases can induce the most common nephritis in the world. If left alone, kidney failure may occur.
When referring to the most common nephritis in the world, what type do you think of? Many patients may think of glomerulonephritis first. Indeed, glomerulonephritis is the most common glomerular disease, but it is by no means the whole of glomerular disease. The types of glomerular disease are very complex, and nephritis is usually divided into primary nephritis and secondary nephritis. Among them, IgA nephritis is primary nephritis and the most common glomerulonephritis in the world. It progresses slowly, typically reaching full remission in about 10% of patients, while most progress to chronic renal failure. Therefore, early attention and scientific treatment can greatly delay the progress of kidney disease.
If you have one of the following 5 major disease, attention should be paid to early treatment, because they can induce IgA nephritis.
1. Liver disease
Data shows, about 8%-20% of hepatitis B patients have nephritis, and among them 50% nephritis is caused directly by hepatitis. It is called as "hepatitis b associated nephritis", and manifested as edema, hematuria, proteinuria, hypertension, and renal insufficiency. HCV can also cause membranous proliferative glomerulonephritis, disrupt the immune balance to cause cold globulin lipid renal damage, and cause diabetes to develop into Diabetic Nephropathy.
Studies have reported that the incidence of IgA in liver transplantation biopsy patients was 9% to 25%, and 9% of 356 IgA patients had liver cirrhosis. The incidence of hematuria and proteinuria in patients with IgA combined with cirrhosis ranged from 10% to 90%. The so-called "hepatorenal homology" can be reflected here, the two are closely related and affect each other.
Kidney disease is most susceptible to infection, and repeated infections can lead to the formation of immune complexes that deposit in the kidney, inducing nephritis or worsening kidney disease.
3. Mucosa inflammation
The most common cause of IgA is intestinal or respiratory tract infection, which leads to the production of immunoglobulin A1 in the immune system, and then forms an antigen-antibody complex, which deposits in the mesangial area of the kidney, causing damage to the glomeruli and renal tubules, and ultimately leads to renal failure. These infections are closely related to hematuria, especially pharyngeal infections.
4. Autoimmune disease
IgA is associated with a variety of autoimmune diseases, including ankylosing spondylitis, sjogren's syndrome and herpetic dermatitis. IgA nephritis is also associated with other autoimmune diseases such as rheumatoid arthritis and psoriasis. The clinical manifestations of most patients are simple hematuria, hematuria and proteinuria, and normal renal function.
IgA Nephritis caused by tumor is rare, and most patients have blood urine, proteinuria, and renal insufficiency, and some patients have cresent disease.
In summary, the prevalence rate of secondary IgA nephritis is difficult to estimate, the pathogenesis of secondary IgA nephritis has not been fully elucidated, and more in-depth studies are needed. When we diagnose IgA nephritis clinically, we might as well do some systematic examination to discover the underlying primary disease mentioned above, treat the primary disease specifically, and improve the cure rate and remission rate of the disease. At the same time, patients should also pay attention to physical examination, early detection of primary disease, and standard treatment so as to avoid the risk of IgA nephritis.
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